Material
ISSN ONLINE : 1880-2400
[School Health Vol.9, 1-5, 2013]
Antibody Against Measles among First Graders: Comparison of the Antibody Titer Before and After the Introduction of the Two-Dose Measles-Rubella Vaccination Program
Chisuzu Toyama*, Seiichiro Nanri*, Mitsuaki Tokumura*,
Mikako Inokuchi*, Shioko Kawai*, Tetsuya Tanaka*, Yuko Tanaka*
and Tetsuo Nakayama**
- *Health Center, Keio University
- 4-1-1 Hiyoshi, Kouhoku, Yokohama, Kanagawa 223-8521 Japan
- c-toyama@adst.keio.ac.jp
- **Kitasato Institute for Life Sciences, Kitasato University
- 5-9-1 Shirogane, Minatoku, Tokyo 108-8641 Japan
[Received July 5, 2010; Accepted October 10, 2012]
- Keywords:
- measles, two-dose, vaccination
Abstracts
To study the effectiveness of two-dose measles vaccination, we examined the antibody titer in
the serum of first graders before and after the introduction of the two-dose measles-rubella
(MR) vaccination program.
A total of 826 first graders (553 boys and 273 girls) who entered school from 2004 to 2009
were studied. We compared the measles IgG antibody in the serum (enzyme immunoassay)
and measles antibody positive rate before and after the introduction of the two-dose MR
vaccination program in 2007.
The measles IgG antibody titer (4.9 ± 1.6) (M ± SD) and antibody positive rate (97.8%) after
the introduction of the two-dose MR vaccination program were significantly higher than the
values (3.3 ± 1.9 and 93.4%, respectively) recorded before its introduction.
We concluded that the implementation of two-dose measles vaccination for preschool children
resulted in a significantly enhanced measles serum antibody titer among first graders. To
eradicate measles, we recommend the two-dose MR vaccination.
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